Search results for " CSF"
showing 5 items of 5 documents
Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients
2015
Abstract Background Several studies suggest that pathological changes in Alzheimer’s disease (AD) brain begin around 10–20 years before the onset of cognitive impairment. Biomarkers that can support early diagnosis and predict development of dementia would, therefore, be crucial for patient care and evaluation of drug efficacy. Although cerebrospinal fluid (CSF) levels of Aβ42, tau, and p-tau are well-established diagnostic biomarkers of AD, there is an urgent need to identify additional molecular alterations of neuronal function that can be evaluated at the systemic level. Objectives This study was focused on the analysis of oxidative stress-related modifications of the CSF proteome, from …
Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynor…
2021
Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown. In this study, we first described the anxious and depression-prone inbred mouse strain, DBA/2J, as an animal model to assess the antidepressant-like effects of ketamine and HNK in vivo. To decode the molecular mechanisms mediating HNK's rapid antidepressant effects, a longitudinal cerebrospinal fluid (CSF) proteome profiling of its acute and sustained effects was conducted using an unbiased, hypothesis-free mass spectrometry-based proteomics app…
Images perceived after chromatic or achromatic contrast sensitivity losses.
2010
Purpose. We simulate how subjects with losses in chromatic and achromatic contrast sensitivity perceive colored images by using the spatiochromatic corresponding pair algorithm. Methods. This is a generalized version of the algorithm by Capilla et al. (J Opt Soc Am (A) 2004;21:176 –186) for simulating color perception of color deviant subjects, which incorporates a simple spatial vision model, consisting of a linear filtering stage, with a band-pass achromatic filter and two low-pass chromatic ones, for the red-green and blue-yellow mechanisms. These filters, except for the global scaling, are the subject’s contrast sensitivity functions measured along the cardinal directions of the color s…
Chronic Adult Hydrocephalus
1974
Knowledge of Wallerian degeneration began in 1852 and, following experimental research on degeneration and regeneration of interrupted nerves, surgeons realized that reinnervation of end organs depended on growth of axons through the interrupted area of nerve. Therefore surgeons tried to reanastomose the stumps. Failures of reinnervation could not be blamed on lack of axoplasma metabolism and flow from cell body to suture line because the clinical observation of amputation neuromas and their constant recurrence demonstrated the unfailing delivery of axoplasma by the nerve cell body; at times to the deep concern of the surgeon, and the constant pain of the patient. The electron microscope sh…
Tau protein as a diagnostic and prognostic biomarker in amyotrophic lateral sclerosis
2020
BACKGROUND AND PURPOSE To test the hypothesis that total tau (tTau), tau phosphorylated at threonine 181 (pTau) and pTau/tTau ratio in the cerebrospinal fluid (CSF) are diagnostic and prognostic biomarkers of amyotrophic lateral sclerosis (ALS), we performed a retrospective observational study in a large cohort of ALS patients and controls. METHODS We enrolled 196 ALS patients and 91 controls, who included patients with ALS-mimicking diseases and those with non-neurodegenerative diseases. All patients underwent lumbar puncture for CSF analysis at the time of the diagnostic evaluation or to first referral. We measured tTau and pTau levels in the CSF by chemiluminescence enzyme immunoassay. R…